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Stephen A Douglas Selected Research

urotensin II

8/2010Chronic urotensin II receptor antagonist treatment does not alter hypertrophy or fibrosis in a rat model of pressure-overload hypertrophy.
9/2009Urotensin II receptor knockout mice on an ApoE knockout background fed a high-fat diet exhibit an enhanced hyperlipidemic and atherosclerotic phenotype.
6/2009Targeted overexpression of the human urotensin receptor transgene in smooth muscle cells: effect of UT antagonism in ApoE knockout mice fed with Western diet.
4/2009The effects of benzodiazepines on urotensin II-stimulated norepinephrine release from rat cerebrocortical slices.
3/2007Urotensin-II Immunoreactivity in Normolipidemic and Hyperlipidemic New Zealand White Rabbits Following Balloon Angioplasty and Stenting.
11/2006Urotensin-II receptor blockade with SB-611812 attenuates cardiac remodeling in experimental ischemic heart disease.
8/2006Urotensin-II blockade with SB-611812 attenuates cardiac dysfunction in a rat model of coronary artery ligation.
12/2005Expression of urotensin-II in human coronary atherosclerosis.
11/2005A role for urotensin II in restenosis following balloon angioplasty: use of a selective UT receptor blocker.
4/2005Cloning and pharmacological characterization of the cat urotensin-II receptor (UT).
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Stephen A Douglas Research Topics

Disease

8Cardiovascular Diseases (Cardiovascular Disease)
08/2010 - 05/2002
5Heart Failure
11/2006 - 06/2002
4Atherosclerosis
09/2009 - 01/2007
4Hypertension (High Blood Pressure)
08/2008 - 12/2003
3Hypertrophy
08/2010 - 10/2004
2Myocardial Infarction
08/2010 - 01/2005
2Fibrosis (Cirrhosis)
08/2010 - 11/2006
2Myocardial Ischemia (Ischemic Heart Diseases)
11/2006 - 05/2005
2Ischemia
12/2005 - 05/2005
2Vascular Remodeling
12/2005 - 11/2005
2Essential Hypertension
03/2004 - 05/2003
2Infections
11/2002 - 08/2002
1Hyperlipidemias (Hyperlipidemia)
09/2009
1Atherosclerotic Plaque (Atheroma)
06/2009
1Mood Disorders (Mood Disorder)
04/2009
1Thrombosis (Thrombus)
03/2009
1Cardiomegaly (Heart Hypertrophy)
06/2007
1Edema (Dropsy)
08/2006
1Coronary Artery Disease (Coronary Atherosclerosis)
12/2005
1Vascular Diseases (Vascular Disease)
12/2005
1Reperfusion Injury
05/2005
1Abdominal Aortic Aneurysm
09/2004
1Rhabdomyosarcoma
07/2004
1Hypoxia (Hypoxemia)
12/2003
1Albuminuria
12/2003
1Inflammation (Inflammations)
12/2003
1Chagas Disease (American Trypanosomiasis)
11/2002
1Cardiomyopathies (Cardiomyopathy)
11/2002
1Heart Diseases (Heart Disease)
08/2002
1Spasm (Spasms)
08/2002
1Renal Cell Carcinoma (Grawitz Tumor)
07/2002

Drug/Important Bio-Agent (IBA)

17urotensin IIIBA
08/2010 - 05/2002
5Peptides (Polypeptides)IBA
09/2009 - 11/2002
3Messenger RNA (mRNA)IBA
06/2007 - 09/2004
3p38 Mitogen-Activated Protein KinasesIBA
06/2007 - 12/2003
3CytokinesIBA
01/2007 - 12/2003
3Endothelin-1 (Endothelin 1)IBA
10/2004 - 08/2002
3Vasoconstrictor AgentsIBA
10/2004 - 05/2003
2UrotensinsIBA
08/2010 - 08/2008
2Apolipoproteins E (ApoE)IBA
09/2009 - 06/2009
2Proteins (Proteins, Gene)FDA Link
06/2009 - 11/2006
2Angiotensin IIIBA
06/2007 - 10/2004
2SB-611812IBA
11/2006 - 08/2006
2CollagenIBA
12/2005 - 11/2005
2G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA
04/2005 - 01/2005
2phosphoramidonIBA
11/2002 - 08/2002
1LipidsIBA
09/2009
1Lipoproteins (Lipoprotein)IBA
09/2009
1Norepinephrine (Noradrenaline)FDA LinkGeneric
04/2009
1Hemin (Panhematin)FDA Link
03/2009
1Heme Oxygenase (Decyclizing) (Heme Oxygenase)IBA
03/2009
1cobaltiprotoporphyrinIBA
03/2009
1Superoxides (Superoxide)IBA
06/2007
1MAP-kinase-activated kinase 2IBA
06/2007
1Arachidonic Acid (Vitamin F)IBA
01/2007
1Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
01/2007
1C.I. direct red 80IBA
11/2006
1Collagen Type I (Type I Collagen)IBA
11/2006
1Rosiglitazone (Avandia)FDA Link
12/2005
1Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)IBA
05/2005
1E-SelectinIBA
05/2005
1Vascular Cell Adhesion Molecule-1 (Vascular Cell Adhesion Molecule 1)IBA
05/2005
1Dexamethasone (Maxidex)FDA LinkGeneric
05/2005
1SB 239063IBA
05/2005
1LysophospholipidsIBA
01/2005
1Interleukin-6 Receptors (Interleukin 6 Receptor)IBA
10/2004
1LigandsIBA
10/2004
1Phenylephrine (Neo-Synephrine)FDA LinkGeneric
10/2004
1Leucine (L-Leucine)FDA Link
10/2004
1Biological ProductsIBA
10/2004
1BIM 23127IBA
10/2004
1Tissue ExtractsIBA
09/2004
1Neurotransmitter Agents (Neurotransmitter)IBA
12/2003
1SaltsIBA
12/2003
1SB-239063ANIBA
12/2003
1Neprilysin (Neutral Endopeptidase)IBA
11/2002
1Metalloproteases (Metalloproteinases)IBA
08/2002
1Endothelin-Converting EnzymesIBA
08/2002

Therapy/Procedure

1Laser Therapy (Surgery, Laser)
03/2009
1Stents
03/2007
1Ligation
11/2006
1Therapeutics
12/2005